blocked (esp. BrE), clogged (AmE)
storm

block (esp. BrE), clog (AmE)
clear, unblock (BrE), unclog (AmE)
lay
They were busy laying the drains for the new houses.

cleaner
a bottle of drain cleaner

heavy, major, serious
emotional, energy
cash, financial
brain
scientists joining the brain drain (= moving to a country where they can work in better conditions and earn more)

drain on
These losses have been a major drain on the company's resources.

thoroughly, well
Remove the artichokes, drain thoroughly and allow to cool.
well-drained soil

poorly
The soil is poorly drained.

quickly, slowly
away, out
The water quickly drained away down the sink.
The surgeon drains out any excess fluid.

out of
The blood drains out of the body.

completely, totally, utterly
emotionally, mentally, physically
away
The country's coal reserves are being drained away.

of
His voice was utterly drained of emotion.

out of
Her energy seemed to drain out of her.

be drained, feel drained
Sue felt exhausted and emotionally drained.

Drain is used with these nouns as the subject:
anger, blood, colour, confidence, strength, tributary

Drain is used with these nouns as the object:
abscess, battery, beaker, bean, can, coffee, cup, energy, fat, fluid, glass, liquid, marsh, mug, pasta, pint, pond, pool, purse, resource, rice, soil, spaghetti, tank, tub, water, will