little, slight, small | ugly | rueful, wry | facial

give, make
She made a wry grimace.

twist into
His face twisted into a grimace.

twist sth
An ugly grimace twisted her face.

with a ~
He acknowledged his mistake with a wry grimace.

~ of
a grimace of disgust/pain

slightly | ruefully, wryly

at
He grimaced slightly at the pain. | She grimaced at him.

in
She grimaced in disgust.