Collocations for helpless - adj.

appear, be, feel, lie, look, seem, stand, watch
John felt completely helpless.
He lay helpless in the hospital ward.

become
leave sb, render sb
He was left helpless and alone.
She was rendered helpless by panic.

absolutely, completely, quite, totally, utterly
apparently, seemingly
almost, virtually
physically

against
She was helpless against his strength.

before
Kirk stood helpless before this giant of a man.

in the face of
I felt helpless in the face of all these rules and regulations.

with
She was helpless with anger.

Helpless is used with these nouns:
creature, gesture, laughter, prey, rage, shrug, tear, victim