big, considerable, enormous, great, heavy, huge, real, tremendous
financial, personal
heroic, noble
final, supreme, ultimate
Soldiers who die for their country have made the supreme sacrifice.

be
I know it's a sacrifice for you, but please try to understand.

make
involve, mean, require
Completing the course will require sacrifice.

animal, human
pagan, religious, ritual
blood

perform
offer (sth as)

sacrifice to
Food and wine were offered as sacrifices to the gods.