natural
wild animals in their natural setting

attractive (esp. BrE), beautiful, ideal, idyllic, lovely (esp. BrE), magnificent (esp. BrE), perfect, picturesque
dramatic
peaceful, tranquil
intimate, romantic
formal, informal
appropriate
rural, urban
outdoor
contemporary
biblical stories in a contemporary setting

public, social, work
The French Club offers the chance to improve your language skills in a social setting.
In a work setting, more formal language would be used.

clinical, experimental, hospital, institutional, laboratory, etc.
academic, classroom, educational, school
cultural, historical
domestic, family
elderly people living in a domestic setting

unfamiliar, unlikely
The hospital is an unlikely setting for an art auction.

create, make, provide
The park provides the perfect setting for the play.

in a/the … setting
a hotel in a beautiful mountain setting

setting for
the perfect setting for a picnic

setting in
The site creates a dramatic setting for the new building.
a dramatic setting in Cornwall

setting of
the urban setting of Manhattan

high, low, medium
default, standard
adjustable
network, security (both computing)
difficulty (= in computer games)
The game has multiple difficulty settings.

adjust, alter, change, modify, tweak
increase, reduce
choose
save (computing)

at a/the setting
The oven should be at a high setting.