Collocations for tiredness - noun

desperate, extreme, overwhelming | mental, physical | chronic, constant

wave
Once the last boxes were packed away, he was overtaken by a wave of tiredness.

be overtaken by, feel, suffer from | relieve

overcome sb
Finally tiredness overcame him, and he fell asleep on the sofa.

set in
A desperate tiredness set in after hours of anxious waiting.

a sign of tiredness
The team was in good spirits and showed no signs of tiredness.